Lymphoma in Dogs

A brown dog sitting down next to text that reads, ‘Understanding Lymphoma’.

Thanks to advances in veterinary medicine, nutrition and good daily care from owners like you, dogs are living longer than ever before. But unfortunately, pets can be diagnosed with cancer, especially as grey creeps into the fur around their faces.

One of the most common pet cancers is lymphoma in dogs. As you might know, cancer occurs when there is uncontrolled division (and proliferation) of abnormal cells. In the case of dog lymphoma, a group of cells in the immune system called lymphocytes go haywire and continue to multiply.

Lymphoma can affect dogs of any breed and any age, but it’s more frequently diagnosed in middle-aged and older dogs.

RISK FACTORS

No one is sure what, exactly, causes lymphoma in dogs.

Since certain breeds, such as golden retrievers, tend to be more affected than others, it’s possible there’s a genetic component to lymphoma in dogs.

SIGNS TO WATCH FOR

Because lymphocytes can travel anywhere in the body, dog lymphoma may be widespread, or it can be localized to particular organs, including the gastrointestinal (GI) tract, spleen, liver, bone marrow, skin, central nervous system or other organs. As a result, the signs can vary, depending on what part of the body is affected. Some pets may just show general signs that they don’t feel well, such as lethargy and loss of appetite.

For lymphoma in dogs, it’s common to have one or more firm, swollen lymph nodes that can be seen or felt in locations such as the neck and behind the knee. The lymph nodes can enlarge quickly and potentially press against other body parts, compromising function. Lymph nodes in the neck, for example, can compress the trachea, making it difficult for the dog to breathe.

LYMPHOMA DIAGNOSIS IN DOGS

The diagnosis is usually made by taking a sample of the malignant cells, either through a fine-needle aspirate or a biopsy of an affected organ. By analyzing a biopsy sample, a specialist can determine whether the cancer is low, intermediate or high grade, depending on how rapidly the cells appear to be dividing. High-grade lymphoma in dogs is typically considered more malignant, but in some cases may be more responsive to treatment.

Other tests may be recommended such as blood tests (including feline leukemia testing in cats) and a urinalysis, to assess the pet’s overall health.

Once a diagnosis is made, dog lymphoma is typically classified by the anatomic area affected, type of lymphocyte (T-cell or B-cell) and by stages, to determine the extent of the disease, potential treatments and prognosis and to monitor response to therapy. Other tests may be needed, including a bone marrow biopsy, X-rays and an ultrasound.

The stages range from I to V, with a single lymph node involvement in stage I to bone marrow or other organ involvement in stage V. Each stage also has a substage, depending on whether the animal is showing signs of illness. Dogs may progress from one stage to the next over time.

PROGNOSIS AND TREATMENT

The prognosis for pets with lymphoma depends on a number of factors including overall health, stage of the disease and type of tumor.

Your veterinarian or a veterinary oncologist (a cancer specialist) can outline treatments that can help your pet feel more comfortable and potentially put the cancer in remission, although this is usually temporary.

Because dog lymphoma is generally considered a systemic disease, some type of chemotherapy is usually recommended. Dogs typically tolerate chemotherapy fairly well, without as many side effects as humans. If the cancer is localized to a specific area, surgery or radiation therapy may be options. Your veterinarian can help you decide the right approach for you and your pet.

Cancer Signs: What to Watch for in Pets

Taste of the Wild

If you’re lucky, you’ll never be faced with a diagnosis of cancer for a pet. But about 1 in 10 dogs and 1 in 5 cats will be diagnosed with cancer in the U.S. this year, according to the Animal Cancer Foundation. We’re sharing pet cancer signs to help you recognize when something may be amiss. After all, early diagnosis and treatment give your pet the best hope for a remission or, in some cases, even a cure.

Of course, the signs of cancer vary depending on the organs or body parts affected, such as the skin, blood or bones. These signs can also signal other conditions, so don’t panic. Just see your veterinarian if you find any of the following:

Unexplained weight loss: If your pet starts looking thinner than usual, and you haven’t started a new diet or exercise routine, it’s time for a checkup.

Enlarged lymph nodes: The lymph nodes that are the easiest to find are just under the jaw, right below the ear and behind the knees. Normally, the lymph nodes feel like a small, pliable blip between your fingers. But if you feel anything firmer or bigger than usual, talk to your veterinarian.

Skin lumps and bumps: You should run your fingers over your pet’s skin at least once a month so you can identify any lumps that are growing or changing. Female pets that have not been spayed are at greater risk for mammary cancer, so be sure to check for any unusual growths on their chests and bellies.

Chronic coughing or difficulty breathing: Tumors that occur in or around the lungs can cause respiratory problems.

Lameness or limb swelling: If you run your hands along both of your pet’s front or rear legs at the same time, it’s easy to compare and spot areas with unusual swellings along the bones. If your pet starts favoring a limb, or is hesitant to bear weight on it, talk to your veterinarian.

Stinky breath or difficulty chewing: These can certainly be signs of periodontal disease, but pets can get tumors in their mouths, as well. If your pet will allow it, take a peek at the gums and under the tongue, checking for unusual growths.

Chronic vomiting or diarrhea: Not surprisingly, cancers of the digestive tract can lead to loose stools, upset stomachs and in some cases, trouble defecating. If the problem persists, or your pet starts losing weight, make an appointment.

Circling or seizures: A pet with a potential brain tumor may experience a sudden onset of seizures, especially in the older years, or may pace in circles over and over again.

Abdominal distension: Pets might have swollen bellies from overindulging in the treat jar, but it can also be a sign of an enlarged organ, such as the liver.

Lethargy:  Any time your pet seems less active than usual, lags behind on walks or just doesn’t want to interact with the family as much, there’s a good chance something’s not right.

When in doubt, see your veterinarian. It may be nothing. But if it’s something more serious, you’ll be glad you caught it early.